Dr. Baxter discovers that the cattle that saloon owner Fancy Varden plans to start her cattle empire with are infected with anthrax, and the disease is spreading from the cattle to the cowhands.
While in San Francisco at a medical convention, Dr. Baxter is framed for murder when a man whom he treated for a routine leg injury dies mysteriously.
Three wanted men are holed up at a ranch house. They kidnap Dr. Baxter to treat one of the men who was shot during a robbery. A hostage, gunfights, and a chase lead to their demise.
A ruthless young woman kills her rich grandfather and tries to frame Dr. Baxter (Rex Allen) for the crime.
